Human diadenosine triphosphate hydrolase: preliminary characterisation and comparison with the Fhit protein, a human tumour suppressor.

A C Asensio; C R Rodríguez-Ferrer; S Oaknin; P Rotllán

doi:10.18388/abp.2000_4023

Human diadenosine triphosphate hydrolase: preliminary characterisation and comparison with the Fhit protein, a human tumour suppressor.

A C Asensio Department of Biochemistry and Molecular Biology, University of La Laguna, Tenerife, Canary Islands, Spain.;
C R Rodríguez-Ferrer
S Oaknin
P Rotllán

DOI: https://doi.org/10.18388/abp.2000_4023

Abstract

Human platelets diadenosine triphosphatase was characterised and compared with the Fhit protein, a human tumour suppressor with diadenosine triphosphatase activity. Both enzymes exhibit similar Km, are similarly activated by Mg2+, Ca2+ and Mn2+, and inhibited by Zn2+ and suramin. However, they are differentially inhibited by Fhit antibodies and exhibit differences in gel-filtration behaviour.

Published

2000-06-30

Issue

Vol. 47 No. 2 (2000)

Section

Articles

Acta Biochimica Polonica is an OpenAccess quarterly and publishes four issues a year. All contents are distributed under the Creative Commons Attribution-ShareAlike 4.0 International (CC BY 4.0) license. Everybody may use the content following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.