Inhibition of tumor growth by interleukin 10 gene transfer in B16(F10) melanoma cells.

S Walos; J Szary; S Szala

doi:10.18388/abp.1999_4120

Inhibition of tumor growth by interleukin 10 gene transfer in B16(F10) melanoma cells.

S Walos Department of Molecular Biology, Center of Oncology-Maria Skłodowska-Curie Memorial Institute, Gliwice, Poland.;
J Szary
S Szala

DOI: https://doi.org/10.18388/abp.1999_4120

Abstract

Interleukin 10 (IL-10) is a potent immunosuppressive cytokine with an antitumor activity. The effect of IL-10 on tumor growth was tested in murine melanoma cells manipulated by gene transfer to secrete IL-10. In mice bearing B16(F10) tumors expressing IL-10 tumor growth was decreased depending on the amount of secreted IL-10.

Published

1999-12-31

Issue

Vol. 46 No. 4 (1999)

Section

Articles

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