Protection of cattle against bovine leukemia virus (BLV) infection could be attained by DNA vaccination.

A Brillowska; S Dabrowski; J Rułka; P Kubiś; E Buzała; J Kur

doi:10.18388/abp.1999_4121

Protection of cattle against bovine leukemia virus (BLV) infection could be attained by DNA vaccination.

A Brillowska Technical University of Gdańsk, Department of Microbiology, Poland.;
S Dabrowski
J Rułka
P Kubiś
E Buzała
J Kur

DOI: https://doi.org/10.18388/abp.1999_4121

Abstract

The bovine leukemia virus (BLV) envelope gene encoding extracellular glycoprotein gp51 and transmembrane glycoprotein gp30 was cloned into a vehicle expression vector under the human cytomegalovirus (CMV) intermediate early promoter. The intramuscular injection of this plasmid vector generated a cellular immune response. Seven out of ten cows vaccinated with the DNA construct resisted a drastic challenge (500 BLV-infected lymphocytes as an infectious dose).

Published

1999-12-31

Issue

Vol. 46 No. 4 (1999)

Section

Articles

Acta Biochimica Polonica is an OpenAccess quarterly and publishes four issues a year. All contents are distributed under the Creative Commons Attribution-ShareAlike 4.0 International (CC BY 4.0) license. Everybody may use the content following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.