DNA repair of adriamycin induced damage in mouse and human cells differing in catalase activity.

B M Gruber; E L Anuszewska

doi:10.18388/abp.1998_4249

DNA repair of adriamycin induced damage in mouse and human cells differing in catalase activity.

B M Gruber Department of Vitamin Drugs, Drug Institute, Warsaw, Poland.;
E L Anuszewska

DOI: https://doi.org/10.18388/abp.1998_4249

Abstract

Catalase is known to counteract cytotoxic effect of adriamycin, used as an anti-neoplastic drug. In cells with low catalase activity no repair of adriamycin induced lesions was observed up to 48 h post treatment. In cells with high catalase activity after 48 h the repair was either complete or partial depending on the human or mouse cell type used.

Published

1998-06-30

Issue

Vol. 45 No. 2 (1998)

Section

Articles

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