Effect of protein kinase ck2 on topoisomerase I from plasmodia of the slime mold Physarum polycephalum.

R A Derlacz; B Kowalska-Loth; K Staroń

doi:10.18388/abp.1998_4270

Effect of protein kinase ck2 on topoisomerase I from plasmodia of the slime mold Physarum polycephalum.

R A Derlacz Institute of Biochemistry, Warsaw University, Warszawa, Poland.;
B Kowalska-Loth
K Staroń

DOI: https://doi.org/10.18388/abp.1998_4270

Abstract

Relaxing activity of Physarum topoisomerase I was increased by calf thymus protein kinase ck2, similarly as was the activity of mammalian topoisomerase I, despite a pronounced difference between amino-acid sequences of non-conserved domains of Physarum and mammalian enzymes. This feature of Physarum topoisomerase I was cancelled in nuclear extracts isolated from dibutyryl-cAMP treated plasmodia in which the activity of protein kinase ck2 was elevated.

Published

1998-09-30

Issue

Vol. 45 No. 3 (1998)

Section

Articles

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