High molecular mass dextran sulfate increases expression of HIV-1 coreceptor CCR-5 in macrophage-monocytes in culture.

P P Jagodzinski; W H Trzeciak

doi:10.18388/abp.1998_4306

High molecular mass dextran sulfate increases expression of HIV-1 coreceptor CCR-5 in macrophage-monocytes in culture.

P P Jagodzinski Department of Physiological Chemistry, University of Medical Sciences, Poznań, Poland.;
W H Trzeciak

DOI: https://doi.org/10.18388/abp.1998_4306

Abstract

It has been reported that high molecular mass dextran sulfate (HMDS) enhances the infection of monocyte-macrophages by HIV-1. We observed that in monocyte-macrophages maintained in the presence of HMDS the expression of HIV-1 coreceptor CCR-5 was increased approximately 5-fold at the transcriptional level. We postulate that the increased expression of CCR-5 might be responsible for HMDS-enhanced infectivity of monocyte-macrophages by HIV-1.

Published

1998-03-31

Issue

Vol. 45 No. 1 (1998)

Section

Articles

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