Some aspects of oligoribonucleotides synthesis via the H-phosphonate approach.

J Stawiński; A Kraszewski

doi:10.18388/abp.1998_4349

Some aspects of oligoribonucleotides synthesis via the H-phosphonate approach.

J Stawiński Stockholm University, Department of Organic Chemistry, Sweden. js@lab12.organ.su.se;
A Kraszewski

DOI: https://doi.org/10.18388/abp.1998_4349

Abstract

This review gives a short account of selected aspects of oligoribonucleotide synthesis via the H-phosphonate method. It includes: (i) recent methods for the preparation of suitably protected ribonucleoside 3'-H-phosphonates (the phosphonylation step), (ii) some chemical and stereochemical features of the formation of H-phosphonate internucleosidic linkages, and (iii) stereoselective synthesis of oligoribonucleoside phosphorothioates using chemo-enzymatic approach.

Published

1998-12-31

Issue

Vol. 45 No. 4 (1998)

Section

Articles

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