New intron-containing human tRNA(Leu) genes.

U Karwowska; Z Szweykowska-Kulińska

doi:10.18388/abp.1997_4383

New intron-containing human tRNA(Leu) genes.

U Karwowska Department of Gene Expression, Adam Mickiewicz University in Poznań, Poland.;
Z Szweykowska-Kulińska

DOI: https://doi.org/10.18388/abp.1997_4383

Abstract

Three new human nuclear tRNA(Leu) genes have been isolated and sequenced using the PCR technique. Two of them represent genes containing a CAA anticodon and both contain introns of 22 nucleotides in length but differing in sequence. Intron-containing prolongated anticodon stems can be folded into a secondary structure similar to that of yeast pre-tRNA(Leu). The evolutionary conserved secondary structure suggests the same role of intron sequences in the human and yeast pre-tRNA(Leu) maturation pathway.

Published

1997-12-31

Issue

Vol. 44 No. 4 (1997)

Section

Articles

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