Characterization of the Escherichia coli gene encoding a new member of the short-chain dehydrogenase/reductase (SDR) family.

A Sirko; A Wegleńska; M Hryniewicz; D M Hulanicka

doi:10.18388/abp.1997_4453

Characterization of the Escherichia coli gene encoding a new member of the short-chain dehydrogenase/reductase (SDR) family.

A Sirko Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland. asirko@ibbrain.ibb.waw.pl;
A Wegleńska
M Hryniewicz
D M Hulanicka

DOI: https://doi.org/10.18388/abp.1997_4453

Abstract

The nucleotide sequence of a chromosomal DNA fragment located upstream from the cysPTWAM operon of Escherichia coli was established. Sequence analysis indicates the presence of an open reading frame which has been designated ucpA (upstream cys P). The potential protein products exhibits strong sequence homology to the members of a large protein family, short-chain dehydrogenases/reductases. Involvement of Crp, FruR and IHF in the regulation of ucpA transcription in vivo was demonstrated.

Published

1997-03-31

Issue

Vol. 44 No. 1 (1997)

Section

Articles

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