Evidence for the presence of different alpha-1-proteinase inhibitor genes products in mouse plasma.

A Dubin; P Mak; J Travis

doi:10.18388/abp.1996_4479

Evidence for the presence of different alpha-1-proteinase inhibitor genes products in mouse plasma.

A Dubin Institute of Molecular Biology, Jagiellonian University, Cracow, Poland.;
P Mak
J Travis

DOI: https://doi.org/10.18388/abp.1996_4479

Abstract

The plasma alpha-1-proteinase inhibitor (API) of three mouse species Mus domesticus, M. caroli and M. pahori was isolated. Each of the species isoforms were then separated by chromatofocusing; however, no significant differences in association rate constants toward human neutrophil elastase and bovine chymotrypsin were observed. The amino-acid sequence of the P'1-P'15 C-terminal fragments of the API variants indicate that mouse plasma contains at least two different active API isoforms in the case of M. domesticus (five API genes) but only one active API isoform in M. pahori and M. caroli (one API gene).

Published

1996-09-30

Issue

Vol. 43 No. 3 (1996)

Section

Articles

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