The levels of glycosphingolipids, ceramides, sialic acid and glycogen are changed in plasma membranes of rat platelets harvested during recovery from immune-mediated thrombocytopenia.

E Zdebska; B Soszyńska; Z Dobrowolski; J Kościelak

doi:10.18388/abp.1996_4490

The levels of glycosphingolipids, ceramides, sialic acid and glycogen are changed in plasma membranes of rat platelets harvested during recovery from immune-mediated thrombocytopenia.

E Zdebska Department of Biochemistry, Institute of Hematology and Blood Transfusion, Warsaw, Poland.;
B Soszyńska
Z Dobrowolski
J Kościelak

DOI: https://doi.org/10.18388/abp.1996_4490

Abstract

Plasma membranes of rat platelets produced at normal platelet counts and during early recovery from immune-mediated thrombocytopenia were examined for the contents of carbohydrates, lipids and glycosphingolipids. Glucosylceramide, two monosialo-gangliosides and one disialo-ganglioside were found to be the major glycosphingolipids of platelets. During thrombocytopenia the contents of these glycosphingolipids as well as of ceramides were several fold elevated. Among carbohydrate constituents of platelets and platelet plasma membranes, glycogen content was increased and that of sialic acid decreased. These results are discussed in the light of literature data on relevant biochemical characteristics of megakaryocytes at different stages of maturation and on thrombopoiesis during acute experimental thrombocytopenia.

Published

1996-09-30

Issue

Vol. 43 No. 3 (1996)

Section

Articles

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