New insights regarding the potential of the pronucleotide approach in antiviral chemotherapy.

G Gosselin; J L Girardet; C Périgaud; S Benzaria; I Lefebvre; N Schlienger; A Pompon; J L Imbach

doi:10.18388/abp.1996_4553

New insights regarding the potential of the pronucleotide approach in antiviral chemotherapy.

G Gosselin Laboratoire de Chimie Bioorganique, URA CNRS 488, Université de Montpellier II, France.;
J L Girardet
C Périgaud
S Benzaria
I Lefebvre
N Schlienger
A Pompon
J L Imbach

DOI: https://doi.org/10.18388/abp.1996_4553

Abstract

The rationale for a pronucleotide approach based on the use of phosphotriesters which incorporate enzyme-mediated bio-labile protection is discussed in detail. Among the studied bio-labile phosphate protecting groups, the S-acyl-2-thioethyl (SATE) groups appeared the most promising as exemplified in cell culture systems in the case of the pronucleotides of 3'-azido-3'-deoxythymidine, 2',3'-didehydro-3'-deoxythymidine, 2',3'-dideoxyadenosine and acyclovir In vivo implementations of such bis(SATE) pronucleotides have been planned for future animal studies.

Published

1996-03-31

Issue

Vol. 43 No. 1 (1996)

Section

Articles

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