Psoralen photosensitization: damages to nucleic acid and membrane lipid components.

S Caffieri; Z Zarebska; F Dall'Acqua

doi:10.18388/abp.1996_4557

Psoralen photosensitization: damages to nucleic acid and membrane lipid components.

S Caffieri Department of Pharmaceutical Sciences, Padua University, Padova, Italy.;
Z Zarebska
F Dall'Acqua

DOI: https://doi.org/10.18388/abp.1996_4557

Abstract

For decades the therapeutic properties of psoralens were related to their photochemical reactions with DNA and RNA. Such approach, although fruitful in treatments, did not explain satisfactorily the way of healing of the multitude of diseases manifested through skin disorders. The new research field presented in our review is directed to another target: the lipid components of the cell. The studies on the photobiology of phospholipids may help to elucidate the phototoxic and pigment inducing activity of psoralens.

Published

1996-03-31

Issue

Vol. 43 No. 1 (1996)

Section

Articles

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