Collagen, elastin and glycosaminoglycans in aortic aneurysms.

K Sobolewski; M Wolańska; E Bańkowski; M Gacko; S Głowiński

doi:10.18388/abp.1995_4588

Collagen, elastin and glycosaminoglycans in aortic aneurysms.

K Sobolewski Department of Biochemistry, Medical Academy of Białystok, Poland.;
M Wolańska
E Bańkowski
M Gacko
S Głowiński

DOI: https://doi.org/10.18388/abp.1995_4588

Abstract

The walls of human abdominal aortas and atherosclerosis-induced aneurysms contain similar amounts of collagen. The quantitative ratio between collagens of various types of this protein does not differ significantly either, whereas solubility of the collagen in aneurysmal wall and its susceptibility to the action of EDTA are distinctly decreased. In contrast with collagen, the amount of elastin in aneurysms is significantly lower. Total amount of glycosaminoglycans slightly decreased as compared with that of normal tissue, but the ratio of particular compounds varies. The percentage of chondroitin sulphate is increased and that of heparan sulphate significantly decreased. The significance of these changes in pathogenesis of aneurysms is discussed.

Published

1995-09-30

Issue

Vol. 42 No. 3 (1995)

Section

Articles

Acta Biochimica Polonica is an OpenAccess quarterly and publishes four issues a year. All contents are distributed under the Creative Commons Attribution-ShareAlike 4.0 International (CC BY 4.0) license. Everybody may use the content following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.