Cereal grain resorcinolic lipids inhibit H2O2-induced peroxidation of biological membranes.

A Kozubek; B Nienartowicz

doi:10.18388/abp.1995_4589

Cereal grain resorcinolic lipids inhibit H2O2-induced peroxidation of biological membranes.

A Kozubek Institute of Biochemistry, Wrocław University, Poland.;
B Nienartowicz

DOI: https://doi.org/10.18388/abp.1995_4589

Abstract

Cereal grain resorcinolic lipids (5-n-alk(en)ylresorcinols) at micromolar concentrations are able to protect the erythrocyte membrane against hydrogen peroxide-induced lipid oxidation. The antioxidative effect is dependent upon chain length of alkylresorcinol molecules. The C15:0 homolog (IC50 of 10 microM) exhibited strongest activity whereas for long chain homologs (C19:0 and C23:0) IC50 values were higher, 32.5 and 59 microM, respectively. The protective effect of alkylresorcinolic antioxidants was also dependent on their incorporation into the membrane, that is governed by their water-membrane partition coefficient. The results obtained show that alkylresorcinols should be recognized as hydrophobic, membrane-localised antioxidants.

Published

1995-09-30

Issue

Vol. 42 No. 3 (1995)

Section

Articles

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