Determination of octanol/water partition coefficients for long-chain homologs of orcinol from cereal grains.

A Kozubek

doi:10.18388/abp.1995_4617

Determination of octanol/water partition coefficients for long-chain homologs of orcinol from cereal grains.

A Kozubek Institute of Biochemistry, University of Wrocław, Poland.;

DOI: https://doi.org/10.18388/abp.1995_4617

Abstract

Polycratic reversed-phase high-performance liquid chromatography (RPHPLC) was used for estimation of the octanol/water partition coefficient for three highly hydrophobic long chain orcinol homologs. The homologs studied (C 15:0, C 17:0 and C 19:0) showed high preference for hydrophobic phase as evidenced by their high octanol/water partition coefficient (log Po/w) values of 7.02-7.74; 8.71-9.47 and 10.49-11.32 for the 95% prediction interval, respectively. Experimentally estimated values were compared with log P values calculated with the use of several fragmental systems. The experimental values of log Po/w are in best agreement to those calculated with the use of the Klopman system (Klopman, G., Namboodiri, K. & Schochet, M., 1985, J. Comput. Chem. 6, 28-38). The lack of appropriate standard compounds with known log Po/w in the range over 6 markedly affected the accuracy of experimental determinations.

Published

1995-06-30

Issue

Vol. 42 No. 2 (1995)

Section

Articles

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