Analysis of the relationship between hemoglobin-oxygen affinity and lipid peroxidation during fever.

M V Borisiuk; V V Zinchuk

doi:10.18388/abp.1995_4670

Analysis of the relationship between hemoglobin-oxygen affinity and lipid peroxidation during fever.

M V Borisiuk Department of Biophysics, Grodno Medical Institute, Republic of Belarus.;
V V Zinchuk

DOI: https://doi.org/10.18388/abp.1995_4670

Abstract

Endogenous hyperthermia was induced in rabbits by i.v. pyrogenal administration. Hemoglobin-oxygen affinity and parameters of free radical lipid oxidation in plasma and red blood cells were measured. The content of diene conjugates, malonic dialdehyde and Schiff bases were determined at a pyrogenal dose of 4 minimal pyrogenic doses/kg, and iron-initiated chemiluminescence, catalase activity and alpha-tocopherol concentration were determined at 6 minimal pyrogenic doses/kg. A rightward shift of the real oxyhemoglobin dissociation curve and activation of lipid peroxidation were observed. Relationships between the parameters measured were analyzed. Decreased hemoglobin-oxygen affinity is considered to be a possible mechanism of activation of free radicals during fever.

Published

1995-03-31

Issue

Vol. 42 No. 1 (1995)

Section

Articles

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