Cis-DDP induced alteration of DNA structure studied by scanning tunneling microscopy.

T H Zastawny; W Olejniczak; R Oliński

doi:10.18388/abp.1993_4798

Cis-DDP induced alteration of DNA structure studied by scanning tunneling microscopy.

T H Zastawny Department of Clinical Biochemistry, Medical School, Bydgoszcz, Poland.;
W Olejniczak
R Oliński

DOI: https://doi.org/10.18388/abp.1993_4798

Abstract

Scanning tunneling microscopy (STM) was used to study the structural changes of DNA induced by the antitumor drug cis-diamminedichloroplatinum. The STM image showed a dramatic structural perturbation of the DNA by complexed Pt with the characteristic bend of the double helix.

Published

1993-12-31

Issue

Vol. 40 No. 4 (1993)

Section

Articles

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