Structural studies of cysteine proteases and their inhibitors.

Z Grzonka; E Jankowska; F Kasprzykowski; R Kasprzykowska; L Lankiewicz; W Wiczk; E Wieczerzak; J Ciarkowski; P Drabik; R Janowski; M Kozak; M Jaskólski; A Grubb

doi:10.18388/abp.2001_5108

Structural studies of cysteine proteases and their inhibitors.

Z Grzonka Department of Organic Chemistry, Faculty of Chemistry, University of Gdańsk, Poland. grzonka@chemik.chem.univ.gda.pl;
E Jankowska
F Kasprzykowski
R Kasprzykowska
L Lankiewicz
W Wiczk
E Wieczerzak
J Ciarkowski
P Drabik
R Janowski
M Kozak
M Jaskólski
A Grubb

DOI: https://doi.org/10.18388/abp.2001_5108

Abstract

Cysteine proteases (CPs) are responsible for many biochemical processes occurring in living organisms and they have been implicated in the development and progression of several diseases that involve abnormal protein turnover. The activity of CPs is regulated among others by their specific inhibitors: cystatins. The main aim of this review is to discuss the structure-activity relationships of cysteine proteases and cystatins, as well as of some synthetic inhibitors of cysteine proteases structurally based on the binding fragments of cystatins.

Published

2001-03-31

Issue

Vol. 48 No. 1 (2001)

Section

Articles

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