Fluorescence decay time distribution analysis of cyclic enkephalin analogues; influence of solvent and Leu configuration in position 5 on conformation.

J Malicka; R Ganzynkowicz; M Groth; C Czaplewski; J Karolczak; A Liwo; W Wiczk

doi:10.18388/abp.2001_5115

Fluorescence decay time distribution analysis of cyclic enkephalin analogues; influence of solvent and Leu configuration in position 5 on conformation.

J Malicka Faculty of Chemistry, University of Gdańsk, Poland.;
R Ganzynkowicz
M Groth
C Czaplewski
J Karolczak
A Liwo
W Wiczk

DOI: https://doi.org/10.18388/abp.2001_5115

Abstract

Lifetime distribution analysis were performed to study the influence of Leu configuration in position 5 on changes of the peptide chain of cyclic analogues of enkephalins containing a fluorescence donor and acceptor in different solvents. The configuration change of Leu5 in all the analogues of enkephalins studied which contain donor-acceptor pairs has no apparent influence on Trp lifetime distributions. In contrast, there is a significant solvent effect on the shape of lifetime distribution.

Published

2001-03-31

Issue

Vol. 48 No. 1 (2001)

Section

Articles

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