RAB11A mediates the proliferation and motility of esophageal cancer cells via WNT signaling pathway

Danyi  Zhao; Bing Wang; Huawei  Chen

doi:10.18388/abp.2020_5392

RAB11A mediates the proliferation and motility of esophageal cancer cells via WNT signaling pathway

Danyi Zhao Department of Gastrointestinal oncology, The Second Hospital of Dalian Medical University, Dalian City, Liaoning Province, 116023, China
Bing Wang Department of Gastrointestinal oncology, The Second Hospital of Dalian Medical University, Dalian City, Liaoning Province, 116023, China https://orcid.org/0000-0001-8537-1668
Huawei Chen Cell Biology Laboratory, Dalian Medical University, Dalian City, Liaoning Province, 116044, China

DOI: https://doi.org/10.18388/abp.2020_5392

Abstract

Esophageal cancer (EC) recently has become a common malignancy of digestive system worldwide. RAB11A is a critical member of the small GTPases superfamily and was reported to affect a variety of cellular functions. However, its potential effects on EC progression and the specific regulatory mechanisms are still unclear. In this study, RAB11A was upregulated in human EC tissues and cells and predicted poor diagnosis. RAB11A expression was correlated with clinical-pathological features including pTNM stage (P=0.001*) and recurrence (P=0.000**) in patients with EC. Furthermore, RAB11A knockdown decreased the proliferation, migration, and invasion of EC cells via WNT pathway in vitro. Subsequently, the in vivo experiments confirmed that RAB11A contributed to EC tumor growth via WNT pathway. Therefore, these results provided evidence showing that RAB11A could promote the progression of EC via WNT pathway and might serve as a promising therapeutic target for EC treatment.

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Published

2020-12-16

Issue

Vol. 67 No. 4 (2020)

Section

Articles

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