Nephro-oncology: clinical and biochemical aspects of kidney disease and cancer - review

Slawomir Lizakowski; Alicja  Dębska-Ślizień; Ilona Kurnatowska; Maciej Jan Zaucha; Marcin Matuszewski; Beata Naumnik; Marcin Adamczak; Jerzy Chudek; Magdalena Durlik; Carla Ferrándiz-Pulido; Bartosz Foroncewicz; Ryszard Gellert; Magdalena Krajewska; Michał Nowicki; Andrzej Więcek; Jolanta Małyszko

doi:10.18388/abp.2020_6588

Slawomir Lizakowski Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdańsk, Poland
Alicja Dębska-Ślizień Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdań77sk, Poland
Ilona Kurnatowska Department of Internal Diseases and Transplant Nephrology, Medical University of Lodz, Łódź, Poland
Maciej Jan Zaucha Department of Hematology and Transplantology, Medical University of Gdansk, Gdańsk, Poland
Marcin Matuszewski Department of Urology, Medical University of Gdansk, Gdańsk, Poland https://orcid.org/0000-0002-7799-685X
Beata Naumnik 1st Department of Nephrology and Transplantation with Dialysis Unit, Medical University of Bialystok, Białystok, Poland https://orcid.org/0000-0001-7090-8856
Marcin Adamczak Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia in Katowice, Katowice, Polan https://orcid.org/0000-0002-0804-1718
Jerzy Chudek Department of Internal Diseases and Oncological Chemotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Poland
Magdalena Durlik Department of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, Poland https://orcid.org/0000-0002-4798-1497
Carla Ferrándiz-Pulido Department of Dermatology. Hospital Universitari Vall d’Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain https://orcid.org/0000-0003-3688-9596
Bartosz Foroncewicz Department of Immunology, Transplantology and Internal Medicine, Medical University in Warsaw, Warsaw, Poland
Ryszard Gellert Department of Nephrology and Internal Medicine, Centre of Postgraduate Medical Education, Bielanski Hospital, Warsaw, Warsaw, Poland
Magdalena Krajewska Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wrocław, Poland https://orcid.org/0000-0002-2632-2409
Michał Nowicki Department of Nephrology, Hypertension and Kidney Transplantation, Medical University of Lodz, Łódź, Poland https://orcid.org/0000-0002-0823-5440
Andrzej Więcek Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia in Katowice, Katowice, Poland
Jolanta Małyszko Department of Nephrology, Dialysis and Internal Medicine, The Medical University of Warsaw, Warsaw, Poland https://orcid.org/0000-0001-8701-8171

DOI: https://doi.org/10.18388/abp.2020_6588

Abstract

Onco-nephrology is a new field of medicine which combines many aspects of kidney injury in cancer patients and cancers in patients with kidney disease. This connection takes many forms and includes drug-induced nephrotoxicity, electrolyte disorders, numerous paraneoplastic syndromes and an increased rate cancers in dialysis and transplanted patients. The appropriate laboratory assessment of the kidney function allows to optimize chemotherapy and thus minimizes the risk of complications. This article focuses on acute kidney injury (AKI), chronic kidney disease (CKD), various electrolyte and acid-base disorders, the most common cancers after kidney transplantation and the kidney disorders associated with HSCT (hematopoietic stem cell transplantation). The possibility of the application of novel cancer therapy, such as cancer immunotherapy and proton therapy in transplant recipients was also discussed.