Bionics investigation of blood 25-hydroxyvitamin D in the interpretable biomechanics diagnosis of childhood anemia

  • Lechi Zhang Department of Rehabilitation Medicine, The Affiliated Su-zhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, 286 Guangji Road, Jiangsu 215008, People’s Republic of China;
  • Aijie Huang Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, 242 Guangji Road, Jiangsu 215008, People’s Republic of China
  • Jingye Cai Department of Child Health Care, Zhang Jiagang Maternity and Child Health Care Hospital, Zhang jiagang, People’s Republic of China
  • Jiangting Hou Department of Child Health Care, Zhang Jiagang Maternity and Child Health Care Hospital, Zhang jiagang, People’s Republic of China
  • Hongyan Deng Department of Child Health Care, Zhang Jiagang Maternity and Child Health Care Hospital, Zhang jiagang, People’s Republic of China
  • Chenxiao Liu Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, 242 Guangji Road, Jiangsu 215008, People’s Republic of China https://orcid.org/0000-0002-0699-9850

Abstract

Vitamin D deficiency (VDD) causes a wide range of health problems, including anemia in infants. If not treated promptly, it may create serious issues for infants with long-term impacts. Therefore, a satisfactory solution to this problem is required. This investigation was to explore the correlation between the blood 25-hydroxyvitamin D (25(OH)D) levels and childhood anemia. In this investigation, a cross-sectional examination was performed on 2,942 babies ranging in age from 2 to 36 months and classified into three cohorts: VDD (Vitamin D deficiency), VDI (Vitamin D insufficiency), and VDS (Vitamin D sufficiency). Multiple-variables and multinomially-related logistic regressions for examining the anemia status-vitamin D (Vit-D) relationship of the baseline as the interpretable visual quality models were examined. The median serum 25(OH)D level in 2,942 infants was 24.72±4.26 ng/l, with 661 cases (22.5%) of VDD and 1710 cases of deficiency (58.1%), and a noticeable seasonal variation (p<0.05). Anemia was present in 28.5% of the VDD group compared with 3.3% in vit-D sufficient infants (p<0.0001). Lower levels of 25(OH)D were found to be associated with an increased risk of anemia in a multiple-variable regression analysis. In healthy children, low 25(OH)D levels were associated with increased risk of anemia. Biologically inspired, primary care physicians should assess Vit-D levels and place a greater emphasis on adequate supplementation for deficiency prevention.

Author Biographies

Lechi Zhang, Department of Rehabilitation Medicine, The Affiliated Su-zhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, 286 Guangji Road, Jiangsu 215008, People’s Republic of China;

 

 

Aijie Huang, Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, 242 Guangji Road, Jiangsu 215008, People’s Republic of China

 

 

Jingye Cai, Department of Child Health Care, Zhang Jiagang Maternity and Child Health Care Hospital, Zhang jiagang, People’s Republic of China

 

 

Jiangting Hou, Department of Child Health Care, Zhang Jiagang Maternity and Child Health Care Hospital, Zhang jiagang, People’s Republic of China

 

 

Hongyan Deng, Department of Child Health Care, Zhang Jiagang Maternity and Child Health Care Hospital, Zhang jiagang, People’s Republic of China

 

 

Published
2023-09-06
Section
Articles