N4-amino-acid derivatives of 6-azacytidine: structure-activity relationship.

I Alexeeva; L Palchikovskaya; A Shalamay; L Nosach; V Zhovnovataya; O Povnitsa; N Dyachenko

doi:10.18388/abp.2000_4066

N4-amino-acid derivatives of 6-azacytidine: structure-activity relationship.

I Alexeeva Institute of Molecular Biology and Genetics NAS of Ukraine, Kiev. shved@imbig.kiev.ua;
L Palchikovskaya
A Shalamay
L Nosach
V Zhovnovataya
O Povnitsa
N Dyachenko

DOI: https://doi.org/10.18388/abp.2000_4066

Abstract

Several N4-derivatives of 6-azacytidine were synthesized using of Vorbrüggen's condensation method. Their antiviral activity with respect to the adenovirus serotypes 2 and 5 in Hep-2 cells culture was studied and primary specific activity was determined. Correlation between chemical structure of new 6-azacytidine derivatives and their biological properties is discussed.

Published

2000-03-31

Issue

Vol. 47 No. 1 (2000)

Section

Articles

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