Vol. 47 No. 1 (2000)

Articles

• A simple model for predicting the free energy of binding between anthracycline antibiotics and DNA.

  W R Rudnicki, M Kurzepa, T Szczepanik, W Priebe, B Lesyng

  1-9

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• Tautomers of styrylquinoline derivatives containing a methoxy substituent: computation of their population in aqueous solution and their interaction with RSV integrase catalytic core.

  M Ouali, C Laboulais, H Leh, D Gill, E Xhuvani, F Zouhiri, D Desmaele, J d'Angelo, C Auclair, J F Mouscadet, M Le Bret

  11-22

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• Molecular modelling, synthesis and antitumour activity of carbocyclic analogues of netropsin and distamycin--new carriers of alkylating elements.

  D Bartulewic, A Markowska, S Wołczyński, M Dabrowska, A Rózański

  23-35

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• Self-organizing neural network for modeling 3D QSAR of colchicinoids.

  J Polański

  37-45

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• The role of side chains in the interaction of new antitumor pyrimidoacridinetriones with DNA: molecular dynamics simulations.

  J Mazerski, I Antonini, S Martelli

  47-57

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• Kinetics of a nucleoside release from lactide-caprolactone and lactide-glycolide polymers in vitro.

  T Kryczka, P Grieb, M Bero, J Kasperczyk, P Dobrzynski

  59-64

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• The intercalation of imidazoacridinones into DNA induces conformational changes in their side chain.

  J Mazerski, K Muchewicz

  65-78

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• Biomimetic polyesters and their role in ion transport across cell membranes.

  Z Jedliński, P Kurcok, G Adamus, M Juzwa

  79-85

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• Synthesis and antimicrobial activity of new adamantane derivatives I.

  A Orzeszko, R Gralewska, B J Starościak, Z Kazimierczuk

  87-94

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• N4-amino-acid derivatives of 6-azacytidine: structure-activity relationship.

  I Alexeeva, L Palchikovskaya, A Shalamay, L Nosach, V Zhovnovataya, O Povnitsa, N Dyachenko

  95-101

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• Effect of ethanol on structural transitions of DNA and polyphosphates under Ca2+ ions action in mixed solutions.

  E V Hackl, Y P Blagoi

  103-112

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• Inhibitory effects of pentamidine analogues on protein biosynthesis in vitro.

  K Bielawski, A Galicka, A Bielawska, K Sredzińska

  113-120

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• N-Methyl-N-D-fructosyl amphotericin B methyl ester (MF-AME), a novel antifungal agent of low toxicity: monomer/micelle control over selective toxicity.

  B Cybulska, I Gadomska, J Mazerski, J G E Borowski, M Cheron, J Bolard

  121-131

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• Comparative studies on cell stimulatory, permeabilizing and toxic effects induced in sensitive and multidrug resistant fungal strains by amphotericin B (AMB) and N-methyl-N-D-fructosyl amphotericin B methyl ester (MFAME).

  J Szlinder-Richert, B Cybulska, J Grzybowska, E Borowski, R Prasad

  133-140

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• The ability of new formamidine sugar-modified derivatives of daunorubicin to stimulate free radical formation in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase and xanthine oxidase.

  J Pawłowska, J Tarasiuk, E Borowski, M Wasowska, I Oszczapowicz, C R Wolf

  141-147

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• c-myc oncogene gene dosage, serum CEA and CA-15.3 antigen levels, and cellular DNA values in relation to ex vivo chemosensitivity of primary human breast cancer.

  B Falkiewicz, C M Schlotter, U Bosse, K Bielawski, U Vogt

  149-156

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• Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay.

  U Vogt, B Falkiewicz, K Bielawski, U Bosse, C M Schlotter

  157-164

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• Cytostatic and cytotoxic effects of (E)-2'-deoxy-2'-(fluoromethylene)-cytidine on a solid tumor and a leukemia cell line.

  P Grie, M Koronkiewicz, J S Skierski

  165-171

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• ATP-binding domain of NTPase/helicase as a target for hepatitis C antiviral therapy.

  P Borowski, O Mueller, A Niebuhr, M Kalitzky, L H Hwang, H Schmitz, M A Siwecka, T Kulikowsk

  173-180

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• Suppressors of translation initiation defect in hem12 locus of Saccharomyces cerevisiae.

  M Góra, K Pluta, A Chelstowska, T Zoładek

  181-190

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• Plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G promoter polymorphism is not associated with breast cancer.

  J Błasiak, B Smolarz

  191-199

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• Reactive oxygen species as second messengers? Induction of the expression of yeast catalase T gene by heat and hyperosmotic stress does not require oxygen.

  Z Krawiec, T Biliński, C Schüller, H Ruis

  201-207

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• Cloning, expression, and crystallization of Cpn60 proteins from Thermococcus litoralis.

  J Osipiuk, M Sriram, X Mai, M W Adams, A Joachimiak

  209-214

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• Temperature-dependent regulatory mechanism of larval development of the wax moth (Galleria mellonella).

  B Cymborowski

  215-221

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• Glutathione conjugation in male reproductive system: studies on glutathione-S-transferase of bull and boar epididymis.

  A Ciszewska-Piłczyńska, A Barańczyk-Kuźma

  223-231

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• Inhibition and activation of enzymes. The effect of a modifier on the reaction rate and on kinetic parameters.

  R Fontes, J M Ribeiro, A Sillero

  233-257

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• An easy procedure to transform the ratio of two polynomials of first degree into Michaelis-Menten-type equations. Application to the ordered Uni Bi enzyme mechanism.

  R Fontes, J M Ribeiro, A Sillero

  259-268

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