Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay.

U Vogt; B Falkiewicz; K Bielawski; U Bosse; C M Schlotter

doi:10.18388/abp.2000_4073

Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay.

U Vogt European Laboratory Association Section Ibbenbüren, Germany. DRUVOGT@t-online.de;
B Falkiewicz
K Bielawski
U Bosse
C M Schlotter

DOI: https://doi.org/10.18388/abp.2000_4073

Abstract

A pilot study on relationships of selected molecular factors [erbB-1, erbB-2, erbB-3, and c-myc oncogene average gene copy numbers (AGCN); steroid receptors and pS2 gene expression; tumor cells' DNA values] to the ex vivo chemosensitivity of ovarian cancer in a modified adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA), was performed. Despite the relatively small number of patients, numerous correlations among the factors tested were found. Nevertheless, only c-myc gene dosage positively affected ex vivo chemosensitivity of tumors tested.

Published

2000-03-31

Issue

Vol. 47 No. 1 (2000)

Section

Articles

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