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Vol. 42 No. 4 (1995)

Published: 1995-12-31

Editorials

Proceedings of the 5th International Symposium on Molecular Aspects of Chemotherapy. Gdansk, Poland, August 21-24, 1995.

Articles

Structural aspects of the inhibition and catalytic mechanism of thymidylate synthase.

L W Hardy

367-380
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Topoisomerase II as a target for anticancer chemotherapy.

S H Kaufmann, R Hancock

381-393
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Advances with phospholipid signalling as a target for anticancer drug development.

G Powis, M Berggren, A Gallegos, T Frew, S Hill, A Kozikowski, R Bonjouklian, L Zalkow, R Abraham, C Ashendel

395-403
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Protein kinase inhibitors--potential chemotherapeutic agents.

D Shugar

405-418
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Simulation of enzyme-substrate interactions: the diffusional encounter step.

R C Wade

419-425
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Aza and diaza bioisosteric anthracene-9,10-diones as antitumor agents.

A P Krapcho, M J Maresch, M P Hacker, E Menta, A Oliva, F C Giuliani, S Spinelli

427-432
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Synthesis and conformational preference of novel 8-fluoroanthracyclines.

P Lombardi, F Animati, A Cipollone, G Giannini, E Monteagudo, F Arcamone

433-444
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Molecular modeling of singlet-oxygen binding to anthraquinones in relation to the peroxidating activity of antitumor anthraquinone drugs.

A Liwo, D Jeziorek, T Ossowski, D Dyl, A Tempczyk, J Tarasiuk, M Nowacka, E Borowski, W Woźnicki

445-456
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Molecular mechanisms of resistance to antifolates, a review.

D Banerjee, E Ercikan-Abali, M Waltham, B Schnieders, D Hochhauser, W W Li, J Fan, R Gorlick, E Goker, J R Bertino

457-464
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Ergosterol biosynthesis inhibition: a target for antifungal agents.

K Barrett-Bee, G Dixon

465-479
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Targeting the fungal plasma membrane proton pump.

B C Monk, A B Mason, T B Kardos, D S Perlin

481-496
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Multiple drug resistance in Candida albicans.

R Prasad, S K Murthy, V Gupta, R Prasad

497-504
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Fungal glycoproteins and their biosynthetic pathway as potential targets for antifungal agents.

W Tanner, M Gentzsch, T Immervoll, A Scheinost, S Strahl-Bolsinger

505-508
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Mechanisms of resistance to azole antifungals.

P Marichal, H Vanden Bossche

509-516
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Evolution and resistance expression of MRSA. Evaluation of beta-lactam antibiotics against a set of isogenic strains with different types of phenotypic expression.

K Asada, Y Inaba, E Tateda-Suzuki, K Kuwahara-Arai, T Ito, K Hiramatsu

517-524
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Rapid non-empirical approaches for estimating relative binding free energies.

A E Mark, Y Xu, H Liu, W F van Gunsteren

525-535
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